GLOBAL Wacker’s CAVACURMIN® led to high Tetrahydrocurcumin bioavailability offering anti-inflammatory, antioxidant properties May 2021

A study recently published in the Journal of Functional Foods showed that ingestion of the curcumin- cyclodextrin complex CAVACURMIN® leads to an increased metabolic bioavailability of tetrahydrocurcumin. A large portion of supplemented curcumin is converted into tetrahydrocurcumin in the body.

This metabolite is credited with anti-inflammatory and antioxidant properties. CAVACURMIN® is the only formulation on the market that demonstrably boosts the bioavailability of both curcumin and tetrahydrocurcumin.

Curcumin, the active compound in turmeric, is a powerful antioxidant that supports healthy aging and joint health, as has been demonstrated in various studies. As it is not water-soluble, curcumin is not readily absorbed in the human bloodstream. Its bioavailability can be boosted significantly with the aid of gamma-cyclodextrin. A study published in 2018 showed that the curcuminoids of Wacker’s cyclodextrin complex CAVACURMIN® are absorbed around 40 times more efficiently in the body than those of a standard curcumin extract.

As part of a randomised double-blind study, it has now been shown that the metabolic bioavailability of tetrahydrocurcumin is also around 40 times higher following ingestion of CAVACURMIN® compared to a standard curcumin extract.

Tetrahydrocurcumin is a curcumin metabolite credited with additional health-promoting properties. The metabolic bioavailability gives the ratio of the in-vivo production of tetrahydrocurcumin to the absorbed amount of curcumin. Another finding of the long-term study is that, after only 4 weeks, daily ingestion of CAVACURMIN® (approx. 340g curcumin each time) leads to a consistently high blood concentration of curcumin and tetrahydrocurcumin. This effect can be measured after 12 weeks as well. The long-term study furthermore confirmed very high tolerability of CAVACURMIN®.

CAVACURMIN®, a product of Wacker Biosolutions, can be easily processed and applied in food supplements such as tablets, capsules and energy bars or functional beverages.

Wacker Biosolutions is a division of the Wacker Chemie AG group which provides tailored, innovative solutions and products to the life-science sector – including pharmaceutical proteins, cyclodextrins and fermentation-generated cysteine. The division focuses on developing customised solutions for growth sectors such as food ingredients, pharmaceutical actives and agrochemicals.




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